Khan is facing a vote to oust him on Sunday.
akistan's Prime Minister Imran Khan on Saturday said the move to remove him was an attempt at regime change backed by the United States.
Khan is facing a vote to oust him on Sunday.
Khan told a group of foreign journalists that, "the move to oust me is (a) blatant interference in domestic politics by the United States".
The White House has denied that the United States is seeking to remove Khan from power after he made similar accusations in the past days.
Khan suggested on Saturday that he might not accept a vote to oust him, a move he alleged was being orchestrated by the United States.
Opposition parties say Khan has failed to revive an economy battered by the coronavirus pandemic or fulfil promises to make his government more transparent and accountable, and have put forward a no-confidence motion due to be voted on Sunday.
"How can I accept the result when the entire process is discredited?" Khan told a select group of foreign journalists at his office. "Democracy functions on moral authority - what moral authority is left after this connivance?"
Khan, who has already lost his parliamentary majority after allies quit his coalition government and joined the opposition, urged his supporters to take to the streets on Sunday ahead of the vote.
Hours before he spoke, the head of the army, General Qamar Javed Bajwa, had said Pakistan wanted to expand its ties with Washington.
US President Joe Biden has not called Khan since taking office, but the White House has denied that it is seeking to topple him.
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