Bellis made headlines by winning a match at last year's U.S. Open, but she couldn't stay with the world's No. 1 player. Williams won 51 of the 65 points and lost only two points in seven service games.

"It wasn't like, 'Oh, I'm so happy to win this match,'" Williams said. "It was tough. She's young and her being an American, you want to see people like her do well."

Williams' opponent in the round of 16 will be 2006 champion Svetlana Kuznetsova, seeded No. 24. She beat No. 13 Angelique Kerber 6-3, 3-6, 6-3.

Williams withdrew before the semifinals at Indian Wells last week, citing an ailing right knee, but hardly had to run against Bellis. Williams hit 13 winners to only one by the teenager, who is the world's top-ranked junior and still an amateur.

"I was pretty nervous," Bellis said. "I mean, she's No. 1 in the world and like the best of all time for a reason. I think it was just a really good experience for me for the future and I'm glad I got to do it, but she's a lot better than me for right now."

On the men's side, Andy Murray's 499th career victory put him in the fourth round. The No. 3-seeded Murray beat Santiago Giraldo 6-3, 6-4 on Sunday, and one more win will give him a milestone achieved by 45 other men in the Open era.

"It's nice, because when you see the list of the players that have won that many matches, there isn't loads," he said. "I obviously want to try and win more, and hopefully still have quite a few years ahead of me left to add to that number."

Eight active men have at least 500 wins. Murray's career record is 499-155, and he'll next face No. 15-seeded Kevin Anderson.

No. 3 Simona Halep, who won Indian Wells a week ago, reached the women's fourth round by beating No. 30 Camila Giorgi 6-4, 7-5.

Two-time champion Victoria Azarenka lost to No. 15 Flavia Pennetta 7-6 (5), 7-6 (6). Azarenka, mounting a comeback from injuries, was playing at Key Biscayne for the first time since 2012.

In other men's play, American Jack Sock lost to Dominic Thiem 6-4, 6-3.

Murray, who won the tournament in 2009 and 2013, is seeking his first title this year. Against Giraldo, Murray lost only four points on his first serve and was broken just once '€” the first time he served for the match.

"Giraldo came out and started swinging a bit toward the end of the match and made it a little bit tricky," Murray said, "but I thought for the most part I played very well."

Giraldo, seeded No. 27, fell to 1-22 against top-10 opponents.

Anderson hit 12 aces and beat No. 24 Leonardo Mayer 6-4, 6-4. A South African, Anderson lives an hour north of Key Biscayne; Murray, a Scotsman, has a home in Miami.

That makes their match an all-Florida affair of sorts.

"Kevin obviously is used to these conditions here," Murray said. "He obviously plays and practices in this weather a lot, so I won't have as much of an advantage against him as maybe some of the guys." (***)

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