Overnight, the S&P 500 climbed 1 percent and the Nasdaq jumped 1.6 percent to notch fresh record-closing highs, helped by a strong start to the earnings season that has eased concerns about the health of the US consumer despite rising energy prices from the Iran war.

MSCI's broadest index of Asia-Pacific shares outside Japan had earlier tracked Wall Street and rallied to a record of 831.56 points, but selling soon kicked in. It was last down 0.7 percent.

Japan's Nikkei vaulted to a new high for a second day before falling over 1 percent. Markets in Taiwan and South Korea also hit new highs and then turned lower.

China's blue chips slipped 0.3 percent and Hong Kong's Hang Seng index fall 0.9 percent

Higher oil prices were partly to blame, with Brent crude futures up another 1.3 percent on Thursday to US$103.18 a barrel, having jumped 3.5 percent overnight to cross back above $100.

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Iran on Wednesday captured two container ships seeking to exit the Gulf via the Strait of Hormuz, tightening its grip on the crucial waterway, as investors watch if the fragile ceasefire in the Middle East will hold.

Nick Twidale, chief market strategist at ATFX Global, said the increased tension in the Middle East is starting to spook investors as further ship seizures erode hopes of more peace talks.

"We saw the spike to record highs on the back of Wall Street's overnight performance, but then the pullback as a bit of a reality check on what is happening in the Middle East."

Wall Street futures fell in Asia after the earnings-driven rally, with Nasdaq futures off 0.5 percent and S&P 500 futures down 0.7 percent. European stock futures are bracing for a much weaker open, with pan-region futures down 1.1 percent.

Shares of GE Vernova surged 13.75 percent after the power equipment maker raised its annual revenue forecast on the AI boom, and Boeing advanced over 5 percent after a smaller-than-expected quarterly loss.

Electric automaker Tesla reported a surprise positive free cash flow in the first quarter, but its projection of sharply higher spending plans on AI and robotics drew skepticism from investors, with its shares down 2 percent after the bell.

Treasury yields edged up. The two-year US Treasury yield rose 2 basis points to 3.8106 percent, after inching up 1 bp on Wednesday. The 10-year yield increased 2 bps to 4.3174 percent, after finishing little changed overnight.

Currencies were mostly calm, with the dollar holding onto small gains from overnight. The euro was steady at $1.17, just above a 10-day low of $1.1691, having lost 0.3 percent overnight.

"Markets have been remarkably effective at looking through risks, and may continue to be. But the list of risks is growing as resolutions remain elusive," said Laura Cooper, global investment strategist at asset manager Nuveen.

"The dissonance cannot hold indefinitely [...] At some point, the weight of what is being ignored could become the only one that matters."

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