The recent case in Reno, Nevada of a woman who died from a rare bacterial infection is a tragic reminder. She picked up a variant of a germ called Klebsiella pneumoniae, probably while she was treated in India for a leg fracture and hip infection, Washoe County health authorities said last week. Tests found the bacterium was resistant to 26 antibiotics. In fact, no available drug could stop it from poisoning her bloodstream weeks after she was admitted to the hospital in Nevada.

The fatal case fits a patterndoctors in North America, Europe and Australia have observed for more than a decade: travelers who have spent time in India have an especially high risk of returning home with unwanted germs. Most often, the drug-evading bugs are ingested in fecally contaminated food or water, and take up residence in the intestines, where they are incorporated into the body’s normal bacterial flora. The stowaways can be dangerous if they escape from the bowel into other tissues, like the bladder or bloodstream.

“There are lots of studies that show that being in India does put you at risk for these infections,” said Ramanan Laxminarayan, a New Delhi-based director for the Center for Disease Dynamics, Economics & Policy in Washington. 

(Read also: Rise of antimicrobial-resistant superbugs)

Babies Dying

India carries one of the highest health-care burdens from antibiotic-resistant bacteria in the world. Sepsis caused by drug-defying germs kills more than 58,000 newborns in India, according to Laxminarayan. The overuse of antimicrobial medicines, and the lack of toilets and clean water, helps propagate and spread the mutant microbes in the environment.

The Indian government is trying to counter that. The direct sale of antibiotics to the public was prohibited in March 2014 to halt excessive, unnecessary use. Later the same year, Prime Minister Narendra Modi began a program to wipe out open defecation within five years as part of a nationwide “Clean India” campaign.

Johann Pitout, a medical microbiologist at the University of Calgary, was one of the first doctors to make the link between travel and the spread of resistant germs. When he arrived in Calgary in 2002, the South Africa-trained doctor noticed that his lab was receiving a disproportionately high number of supergerm-containing patient specimens from general practitioners and nursing homes, instead of hospitals – typically the biggest source of hard-to-kill bacteria.

The microbes that piqued Pitout’s interest were common intestinal-dwelling bacteria that harbored special enzymes, known as extended-spectrum beta-lactamases (ESBLs), which destroy most penicillin- and cephalosporin-based antibiotics.

“ESBLs were mostly in the community setting, which was the first time I’d ever seen that,” Pitout said in an interview. He began surveying patients to understand why, and found the answer in responses to a question on travel history. “The majority of patients had previously traveled to India and China. Those were the two places that stood out.”

(Read also: Save our lives, use antibiotics wisely)

India is predicted to be the world’s third-biggest air travel market by 2035. (Thomas Tangden et al, in Antimicrobial Agents and Chemotherapy, Sept. 2010 via Bloomberg/File)

Travel Destination

India is predicted to be the world’s third-biggest air travel market by 2035. Since Pitout noted the infection link, the South Asian nation has come up as the country from where travelers are most likely to return with digestive tracts colonized by ESBL-producing bacteria in at least eight studies by research groups from Australia to New York City.

In one study, doctors in Sweden tested rectal swabs from 105 volunteers who were about to travel internationally. Only one already had E. coli with the drug-resistance enzyme before departure. Of the remaining 104 travelers, 100 provided a second rectal swab on returning to Sweden, 24 of whom were colonized with ESBL-producing bacteria. Of the eight who traveled to India, seven carried the superbug in their digestive tract.

Taking an antibiotic, such as for travelers’ diarrhea, significantly increases the risk because it disturbs normal gut flora, allowing new intestinal microbes to take hold, Pitout said.

Prostate Biopsy

Once inside the bowel, the supergerms can migrate to cause a difficult-to-treat urinary tract infection. They also pose a risk for men undergoing a prostate biopsy or anyone having bowel or gallbladder surgery, said Peter Collignon, head of infectious diseases at Canberra Hospital, who sits on a panel advising the World Health Organization about antimicrobial resistance.

Patients hospitalized with an invasive, ESBL infection are usually treated with a medicine from the carbapenem class, though even those high-powered antibiotics are failing now that bacteria are increasingly harboring carbapenemase enzymes that neutralize these drugs. In many cases, that leaves just one antibiotic: colistin. That too is losing its potency, thanks to a bacterial gene first identified in China that’s since turned up in at least 20 countries.

(Read also: Getting ready to tackle 'superbugs' on farms, food)

The recent case in Reno, Nevada of a woman who died from a rare bacterial infection is a tragic reminder. She picked up a variant of a germ called Klebsiella pneumoniae, probably while she was treated in India for a leg fracture and hip infection, Washoe County health authorities said last week. (Shutterstock/File)

Trips to China

That finding and other recent studies show antimicrobial resistance is a growing worldwide problem, with an especially high incidence in countries in South Asia, Southeast Asia, China, and some areas in southern Europe, such as Greece, said Lindsay Grayson, head of infectious diseases at the Austin Hospital in Melbourne.

“The extent of the spread of these organisms and the size of the problem is still being defined,” Grayson said in a phone interview from Geneva, where he is assisting WHO formulate clinical guidelines to control the spread. “In Australia, we have increasing concerns about travelers, such as businessmen, who have recently returned from China who are about to undergo surgical procedures. They should undergo fecal screening to see if they have acquired similarly resistant organisms that could later affect their health care.”

Swedish Patient

The bacterium that killed the woman in Nevada resisted carbapenem as well as colistin. It was fortified with a gene dubbed NDM -- short for New Delhi metallo-beta-lactamase, a reference to the city where a Swedish man was hospitalized in 2007 with an infection that couldn’t be stopped by carbapenem or any commonly prescribed antibiotic treatment.

The gene is now found in bacteria worldwide, including in the U.S., making it impossible to prove whether or not the Nevada patient, who was in her 70s, picked it up during her extended visit to India, said Laxminarayan at the Center for Disease Dynamics, Economics & Policy. Even still, it’s plausible that India was the source.

“Carbapenem-resistance is rife in India -- both in the community and in hospitals,” he said.